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Recombinant Human DR6/TNFRSF21 Protein (Fc Tag)

Uniprot : O75509
  • Cat.No.:PKSH032346

  • Expression host: HEK293 Cells

To Purchase PKSH032346

  • 10μg
  • 50μg
Price: $74


Synonyms Tumor Necrosis Factor Receptor Superfamily Member 21;Death Receptor 6;CD358;TNFRSF21;DR6
Species Human
Expression_host HEK293 Cells
Sequence Gln42-Leu350
Accession O75509
Mol_Mass 61.7 kDa
AP_Mol_Mass 80-90 kDa
Tag C-Fc


Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.


Tumor Necrosis Factor Receptor Superfamily Member 21 (TNFRSF21) is a type I transmembrane receptor that includes four extracellular cysteine-rich motifs and a cytoplasmic death domain. DR6 is highly expressed in heart, brain, placenta, pancreas, lymph node, thymus and prostate. DR6 may activate NF-kappa-B and JNK to promote apoptosis and T-cell differentiation. In addition, DR6 binds with N-APP, which is released by the deprivation of Trophic-factor. It triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). DR6 is also expressed on the tumor cell lines and can be induced by TNF-α.

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