Recombinant Human FANCA/FACA Protein (His Tag) (PKSH030946)
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For research use only.
| Synonyms | FA, FA-H, FA1, FAA, FACA, FAH, FANCH |
| Species | Human |
| Expression Host | Baculovirus-Insect Cells |
| Sequence | Met 1-Cys 297 |
| Accession | AAH08979.1 |
| Calculated Molecular Weight | 35.2 kDa |
| Observed Molecular Weight | 35 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Form | Liquid |
| Purity | > 85 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile 20mM Tris, 200mM NaCl, pH 8.5, 20% gly, 0.1% Triton, 1mM TCEP |
| Background | FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by hypersensitivity to DNA-damaging agents and oxidative stress. FANCA associates with the IκB kinase (IKK) signalsome via interaction with IKK2. Components of the FANCA complex undergo rapid, stimulus-dependent changes in phosphorylation, which are blocked by kinase-inactive IKK2. |
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