Synonyms	apoptosis (APO-1) antigen ligand 1;Apoptosis antigen ligand;APT1LG1CD95L;APTL;CD178 antigen;CD178;CD95L;CD95-L;Fas antigen ligand;Fas ligand (TNF superfamily;member 6);Fas Ligand;FASLCD95 ligand;FASLG;TNFSF6
Species	Human
Expression_host	HEK293 Cells
Sequence	Pro134-Leu281
Accession	P48023
Mol_Mass	17.7 kDa
AP_Mol_Mass	20-30 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution	Not Applicable

Background

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its ability to induce apoptosis in target cells plays an important role in the development, homeostasis, and function of the immune system. Interaction of FAS with fas Ligand is critical in triggering apoptosis of some types of cells such as lymphocytes. Fas Ligand may be involved in cytotoxic T-cell mediated apoptosis and in T-cell development. TNFRSF6/FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

Citations

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