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Recombinant Human FAS/TNFRSF6 Protein (Fc Tag)

  • Cat.No.:PKSH032413

  • Expression host: Human Cells

To Purchase PKSH032413

  • 10μg
  • 50μg
Price: $263


Synonyms Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor; APT1; FAS1; TNFRSF6 and FAS
Species Human
Expression_host Human Cells
Sequence Gln26-Asn173
Accession P25445
Mol_Mass 44.6 kDa
AP_Mol_Mass 60 kDa
Tag C-Fc


Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Formulation Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Please refer to the printed manual for detailed information.


FAS(TNFRSF6) is a receptor and contains three TNFR-Cys repeats and one death domain. It has been shown that FAS is involved in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. FADD (adapter molecule) recruits caspase-8 to the activated receptor, the resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases mediating apoptosis. FAS-mediated apoptosis may play a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.

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