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Current Position:Home>>Protein Products>>Recombinant Proteins>> Recombinant Human FcRn & B2M Heterodimer (C-6His-Avi) Biotinylated

Recombinant Human FcRn & B2M Heterodimer (C-6His-Avi) Biotinylated

  • Cat.No.:PKSH033906

  • Expression host: HEK293 Cells
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Description

Synonyms IgG receptor FcRn;Neonatal Fc receptor;FCRN
Species Human
Expression_host HEK293 Cells
Sequence Ala24-Ser297&Ile21-Met119
Accession AAF72596&P61769
Mol_Mass 31.1&13.5 kDa
AP_Mol_Mass 35&13 kDa
Tag C-His-Avi
Bio_Activity Loaded Biotinylated Human FcRn Heterodimer-His-Avi on HIS1K Biosensor, can bind Anti-Human HER2 mAb with an affinity constant of 0.11 uM as determined in BLI assay.

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 6% Sucrose, 4% Mannitol, 0.05% Tween 80, pH 7.8.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer i
Reconstitution Please refer to the printed manual for detailed information.

Background

FcRn complex consist of two subunits: IgG receptor FcRn large subunit p51（alpha chain) and Beta-2-microglobulin（Beta chain). The complexes is similar in structure to MHC class I-like heterodimer. Beta-2-microglobulin involved in the presentation of peptide antigens to the immune system. FcRn binds to the Fc region of monomeric immunoglobulins gamma, mediates the uptake of IgG from milk,Possible role in transfer of immunoglobulin G from mother to fetus. A principal component of antibody transport is the neonatal receptor for the Fc portion of immunoglobulin, a heterodimer of a MHC-1 alpha-chain homolog ( FcRn ) and beta-2-microglobulin ( B2M ).

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