Recombinant Human FGF-23 protein(His Tag) (PKSH034162)
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For research use only.
| Synonyms | FGFN |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Tyr 25-Ile 251 |
| Accession | Q9GZV9 |
| Calculated Molecular Weight | 26.3 kDa |
| Observed Molecular Weight | 26 kDa |
| Tag | C-His |
| Bio-activity | Measure by its ability to induce proliferation in BaF3 cells transfected with human FGFRIIIc.The ED50 for this effect is <0.3 μg/mL. |
| Form | Lyophilized powder |
| Purity | > 98 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.1 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation |
Lyophilized from sterile PBS,pH 8.0. Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Up-regulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. |
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