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Recombinant Human FN14/TWEAKR Protein (Fc Tag)

  • Cat.No.:PKSH033168

  • Expression host: Human Cells

To Purchase PKSH033168

  • 10μg
  • 50μg
Price: $117


Synonyms CD266;FN14;TWEAKRTNFRSF12A;Fibroblast growth factor-inducible immediate-early response protein 14; FN14
Species Human
Expression_host Human Cells
Sequence Glu28-Trp79
Accession Q9NP84
Mol_Mass 35.6 kDa
AP_Mol_Mass 35 kDa
Tag C-Fc


Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
Reconstitution Please refer to the printed manual for detailed information.


Tumor necrosis factor receptor superfamily member 12A(TNFRSF12A) is also known as Fibroblast growth factor-inducible immediate-early response protein 14, FN14, CD266 antigen and tweak-receptor. TNFRSF12A is a single-pass type I membrane protein, including a 27 aa signal peptide, a 53 aa extracellular domain, a 21 aa transmembrane domain and a 28 aa cytoplasmic domain. TNFRSF12A is highly expressed in heart, placenta and kidney. TNFRSF12A can be induced by FGF1 and phorbol ester. TNFRSF12A binds to TWEAK/TNFSF12A to initiate a signal transduction cascade, causing different cellular responses such as cell death, cell proliferation, and angiogenesis.

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