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Recombinant Human GADD45β/GADD45B Protein (His Tag)

Uniprot : O75293
  • Cat.No.:PKSH032467

  • Expression host: E.coli

To Purchase PKSH032467

Size:
  • 10μg
  • 50μg
Price: $178
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Description

Synonyms Growth Arrest and DNA Damage-Inducible Protein GADD45 Beta;Myeloid Differentiation Primary Response Protein MyD118;Negative Growth Regulatory Protein MyD118;GADD45B;MYD118
Species Human
Expression_host E.coli
Sequence Met 1-Arg160
Accession O75293
Mol_Mass 20.0 kDa
AP_Mol_Mass 24 kDa
Tag N-His
Bio_Activity Not validated for activity

Properties

Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.

Background

Growth Arrest and DNA Damage-Inducible Protein GADD45 β (GADD45B) is a member of the GADD45 family. GADD45B has been shown to interact with MAP3K4, ASK1, MAP2K7, and GADD45GIP1. GADD45B is involved in the regulation of growth and apoptosis. GADD45B reacts to environmental stresses by mediating activation of stress-responsive MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. In addition, GADD45B participates in the down-regulation of hepatocellular carcinoma (HCC). It may serve as a possible therapeutic target.

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