Recombinant Human GDF5/BMP-14 Protein

    • Recombinant Human GDF-5 / BMP-14 Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human GDF-5 / BMP-14 Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human GDF-5 / BMP-14 Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033660

      Synonyms:Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin; CDMP1

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $74

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      Overview

      Synonyms Growth/differentiation factor 5; GDF-5; Bone morphogenetic protein 14; BMP-14; Cartilage-derived morphogenetic protein 1; CDMP-1; Lipopolysaccharide-associated protein 4; LAP-4; LPS-associated protein 4; Radotermin; CDMP1
      Species Human
      Expression_host E.coli
      Sequence Ala382-Arg501
      Accession P43026
      Mol_Mass 13.7 kDa
      AP_Mol_Mass 15 kDa

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGFβ superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is synthesized as a homodimeric precursor protein consisting of a 354 amino acid (aa) Nterminal proregion and a 120 aa C-terminal mature peptide. Mature human GDF-5 shares 99% aa sequence identity with both mature mouse and rat GDF-5. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in multiple developmental processes including limb generation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. Inhibition of GDF-5 expression or alteration of its signaling can facilitate the development of osteoarthritis.

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      MSDS for ELISA ISO 9001

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