Recombinant Human GITR/TNFRSF18 Protein (mFc Tag)
Price: $ 297
Price: $ 117
Size:
50μg
10μg
Quantity:
- Expression Host: HEK293 Cells
- Accession: Q9Y5U5
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Product Details
Synonyms | Tumor necrosis factor receptor superfamily member 18;TNFRSF18;Glucocorticoid-induced TNFR-related protein;CD357;TNFRSF18;AITR;GITR |
Species | Human |
Expression Host | HEK293 Cells |
Sequence | Gln26-Glu161(Thr45Ala) |
Accession | Q9Y5U5 |
Calculated Molecular Weight | 41.1 kDa |
Observed Molecular Weight | 40-55 kDa |
Tag | C-mFc |
Purity | > 90 % as determined by reducing SDS-PAGE. |
Endotoxin | < 1.0 EU per μg of the protein as determined by the LAL method. |
Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
Formulation |
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual. |
Reconstitution | Please refer to the printed manual for detailed information. |
Background | Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1; TRAF2; and TRAF3; but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation. |