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Recombinant Human GNS Protein (His Tag)

Uniprot : P15586
  • Cat.No.:PKSH032779

  • Expression host: HEK293 Cells

To Purchase PKSH032779

  • 10μg
  • 50μg
Price: $223


Synonyms N-Acetylglucosamine-6-Sulfatase;Glucosamine-6-Sulfatase;G6S;GNS
Species Human
Expression_host HEK293 Cells
Sequence Val37-Leu552
Accession P15586
Mol_Mass 59.4 kDa
AP_Mol_Mass 87 kDa
Tag C-His


Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.0.
Reconstitution Not Applicable


N-Acetylglucosamine-6-Sulfatase is a member of the Sulfatase family. N-Acetylglucosamine-6-Sulfatase is required for the lysosomal degradation of the Glycosaminoglycans (GAG) Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase hydrolyzes the 6-Sulfate groups of the N-Acetyl-D-Glucosamine 6-Sulfate units of Heparan Sulfate and Keratan Sulfate. N-Acetylglucosamine-6-Sulfatase binds 1 Calcium ion per subunit. N-Acetylglucosamine-6-Sulfatase deficiency are the cause of Mucopolysaccharidosis Type 3D (MPS3D), an inborn error leading to lysosomal accumulation of heparan sulfate. MPS3D has profound mental deterioration, hyperactivity, and relatively mild somatic manifestations.



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