Recombinant Human HGF Protein (His Tag) (PKSH032538)
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For research use only.
| Synonyms | Hepatocyte growth factor, Hepatopoietin-A, HGF, HPTA, Scatter factor, SF |
| Species | Human |
| Expression Host | HEK293 Cells |
| Sequence | Gln32-Ser728 |
| Accession | P14210 |
| Calculated Molecular Weight | 26&53.7 kDa |
| Observed Molecular Weight | 32-38&50-65 kDa |
| Tag | C-His |
| Bio-activity | Measured by its ability to induce IL-11 secretion by Saos‑2 human osteosarcoma cells. The ED50 for this effect is 0.3-1. 5 ng/ml. |
| Form | Lyophilized powder |
| Purity | > 95 % as determined by reducing SDS-PAGE. |
| Endotoxin | < 0.01 EU per μg of the protein as determined by the LAL method. |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution of 20mM Tris，500mM NaCl，3%Trehalose，0.02% Tween 80，pH 8.0. |
| Reconstitution | Please refer to the printed manual for detailed information. |
| Background | Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It belongs to the peptidase S1 family and Plasminogen subfamily, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. HGF is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. |
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