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Recombinant Human HLA-A*0201 NY-ESO-1 complex Protein (C-10His)

Uniprot : P61769&P01892

Cat.No.:PKSH034036
Expression host: HEK293 Cells

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Description

Synonyms	MHC;MY-ESO-1;HLA-A*0201 NY-ESO-1 complex Protein
Species	Human
Expression_host	HEK293 Cells
Sequence	SLLMWITQC&Ile21-Met119&Gly25-Ile308(Ala269Val)
Accession	P61769&P01892
Mol_Mass	49.1 kDa
AP_Mol_Mass	55-60 kDa
Tag	C-His

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 500mM NaCl, pH7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manu
Reconstitution	Please refer to the printed manual for detailed information.

Background

NY-ESO-1 is a well-known cancer-testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit spontaneous humoral and cellular immune responses, together with its restricted expression pattern, have rendered it a good candidate target for cancer immunotherapy. Optimally assembled peptide-HLA-B2M trimer translocates to the surface of antigen-presenting cells, where it interacts with TCR and CD8 coreceptor on the surface of T cells.

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