Recombinant Human HO1 Protein(Trx Tag) (PDEH100474)
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For research use only.
| Synonyms | 32 kD, 32-kD, bK286B, bK286B10, D8Wsu38e, heat shock protein, heat shock protein 32 kD, heat shock protein 32kD, heme oxygenase, heme oxygenase (decycling), heme oxygenase (decycling) 1, heme oxygenase 1, Hemox, Hmox, HMOX 1, HMOX1, HMOX1D, HO, HO 1, HO-1, HO-1 HMOX, HO-1 HMOX1, HO1, HSP, HSP32 |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met1-Thr261 |
| Accession | P09601 |
| Calculated Molecular Weight | 48.7 kDa |
| Observed Molecular Weight | 48 kDa |
| Tag | N-Trx |
| Bio-activity | Not validated for activity |
| Form | Lyophilized powder |
| Purity | > 95% as determined by reducing SDS-PAGE. |
| Endotoxin | < 10 EU/mg of the protein as determined by the LAL method |
| Storage | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping | This product is provided as lyophilized powder which is shipped with ice packs. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Background | Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, endotoxin, oxidizing agents and UVA. HO-1 is involved in the regulation of cardiovascular function and response to a variety of stressors. Defects in HO-1 are the cause of Heme Oxygenase 1 deficiency, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. |
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