Recombinant Human HVEM/TNFRSF14 Protein (mFc Tag)

    • Recombinant Human HVEM / TNFRSF14 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human HVEM / TNFRSF14 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human HVEM / TNFRSF14 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033656

      Synonyms:Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $86

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      Overview

      Synonyms Tumor Necrosis Factor Receptor Superfamily Member 14; Herpes Virus Entry Mediator A; Herpesvirus Entry Mediator A; HveA; Tumor Necrosis Factor Receptor-Like 2; TR2; CD270; TNFRSF14; HVEA; HVEM
      Species Human
      Expression_host Human Cells
      Sequence Pro37-Val202
      Accession Q92956
      Mol_Mass 44.1 kDa
      AP_Mol_Mass 55-90 kDa
      Tag C-mFc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, 150mM NaCl, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Herpesvirus entry mediator (HVEM) is a type I membrane protein in the TNF receptor superfamily, and it can both promote and inhibit T cell activity. HVEM is highly expressed on na?ve CD4+ T cells, CD8+ T memory cells, regulatory T cells, dendritic cells, monocytes, and neutrophils. It functions as a receptor for BTLA, CD160, LIGHT/TNFSF14, and Lymphotoxin-alpha. Ligation of HVEM by LIGHT triggers T cell, monocyte, and neutrophil activation and contributes to Th1 inflammation and cardiac allograft rejection. In contrast, HVEM binding to CD160 or BTLA suppresses T cell and dendritic cell activation and dampens intestinal inflammation. HVEM enhances the development of CD8+ T cell memory and Treg function. It is additionally expressed on intestinal epithelial cells, where its binding by intraepithelial lymphocyte (IEL) expressed CD160 promotes epitheilal integrity and host defense. The herpesvirus envelope glycoprotein gD, which binds HVEM to initiate membrane fusion, can antagonize both BTLA and LIGHT binding.

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      MSDS for ELISA ISO 9001

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