Recombinant Human IgG2-Fc Protein (aa 104-326, Val161Met)

    • Recombinant Human IgG2-Fc Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human IgG2-Fc Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human IgG2-Fc Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033653

      Synonyms:Ig gamma-2 chain C region,IgG2 Fc

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $37

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Ig gamma-2 chain C region,IgG2 Fc
      Species Human
      Expression_host Human Cells
      Sequence Val104-Lys326(Val161Met)
      Accession P01859
      Mol_Mass 25.1 kDa
      AP_Mol_Mass 32 kDa

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      As a monomeric immunoglobulin that is predominately involved in the secondary antibody response and the only isotype that can pass through the human placenta, Immunoglobulin G (IgG) is synthesized and secreted by plasma B cells, and constitutes 75% of serum immunoglobulins in humans. IgG antibodies protect the body against the pathogens by agglutination and immobilization, complement activation, toxin neutralization, as well as the antibody-dependent cell-mediated cytotoxicity (ADCC). IgG tetramer contains two heavy chains (50 kDa ) and two light chains (25 kDa) linked by disulfide bonds, that is the two identical halves form the Y-like shape. IgG is digested by pepsin proteolysis into Fab fragment (antigen-binding fragment) and Fc fragment ("crystallizable" fragment). IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR ) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues. Protein G or Protein A on the surface of certain Staphylococcal and Streptococcal strains specifically binds with the Fc region of IgGs, and has numerous applications in biotechnology as a reagent for affinity purification. Recombinant IgG Fc Region is suggested to represent a potential anti-inflammatory drug for treatment of human autoimmune diseases.

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