Synonyms	CD212;IL-12R-BETA1;IL12RB;IMD30;CD212 antigen;IL-12 receptor beta component;IL-12 receptor subunit beta-1;IL12R;IL-12R subunit beta-1;IL12RB;IL-12RB1;IL-12R-BETA1;IL-12R-beta-1;interleukin-12 receptor beta-1 chain;interleukin-12 receptor subunit beta-1
Species	Human
Expression_host	HEK293 Cells
Sequence	Cys24-Glu540
Accession	P42701
Mol_Mass	84.2 kDa
AP_Mol_Mass	95-110 kDa
Tag	C-Fc

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 5% trehalose, 5% mannitol, 0.02% Tween80, pH8.0. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific bu
Reconstitution	Please refer to the printed manual for detailed information.

Background

Interleukin12 receptor subunit beta 1 (IL12RB1) is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. IL12RB1 can spontaneously form homodimers and -oligomers; which are able to bind IL12 with only low affinity. IL12 high affinity receptor complex is composed of two subunits designated IL12RB1 and IL12RB2. While IL12RB1 interacts with the IL-12p40 subunit; IL-12p35 is mainly connecting with IL12RB2. This receptor chain is also responsible for transmitting the IL12 signal into the cell. IL12RB1; to the contrary; is also part of the IL23R; where it interacts with the p40 subunit of IL23. IL12RB1 is expressed in activated T cells; NK cells and B cells.

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