Recombinant Human IL-1RA/IL1RN Protein

    • Recombinant Human IL-1RA / IL1RN Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human IL-1RA / IL1RN Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human IL-1RA / IL1RN Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033633

      Synonyms:Interleukin-1 Receptor Antagonist Protein; IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 Inhibitor; Anakinra; IL1RN; IL1F3; IL1RA

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $49

      Lead Time: Order now, ship in 3 daysWelcome to order from local distributors.

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      Overview

      Synonyms Interleukin-1 Receptor Antagonist Protein; IL-1RN; IL-1ra; IRAP; ICIL-1RA; IL1 Inhibitor; Anakinra; IL1RN; IL1F3; IL1RA
      Species Human
      Expression_host E.coli
      Sequence Arg26-Glu177
      Accession P18510
      Mol_Mass 17.26 kDa
      AP_Mol_Mass 18 kDa

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 50mM TrisHCl, 200mM NaCl, pH 7.5.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune and chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 and IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble and intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.

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