Recombinant Human IL-6/Interleukin-6 Protein (Active)

    • Recombinant Human IL-6 / Interleukin-6 Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human IL-6 / Interleukin-6 Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human IL-6 / Interleukin-6 Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033611

      Synonyms:Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2;BSF2;HGF;HSF;IFNB2

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $144

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      Overview

      Synonyms Interleukin-6; IL-6; B-Cell Stimulatory Factor 2; BSF-2; CTL Differentiation Factor; CDF; Hybridoma Growth Factor; Interferon Beta-2; IFN-Beta-2; IL6; IFNB2;BSF2;HGF;HSF;IFNB2
      Species Human
      Expression_host E.coli
      Sequence Val30-Met212
      Accession P05231
      Application Cell Culture
      Mol_Mass 20.9 kDa
      AP_Mol_Mass 20 kDa
      Bio_Activity Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. The ED50 for this effect is 20-100pg/ml.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Cytokines of the IL6/GCSF/MGF family are glycoproteins of about 170 to 180 amino acid residues that contain four conserved cysteine residues involved in two disulfide bonds. They have a compact, globular fold (similar to other interleukins), stabilized by the 2 disulfide bonds. One half of the structure is dominated by a 4 alpha-helix bundle with a left-handed twist; the helices are anti-parallel, with 2 overhand connections, which fall into a 2-stranded anti-parallel beta-sheet. The fourth alpha helix is important to the biological activity of the molecule. Interleukin-6 (IL-6) is an important proinflammatory and immunoregulatory cytokine expressed by various cells. Interleukin-6 has been shown to inhibit the growth of early stage and to promote the proliferation of advanced stage melanoma cells in vitro.

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      MSDS for ELISA ISO 9001

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