Recombinant Human Interleukin-15/IL-15 Protein (Active)

    • Recombinant Human IL-15 / Interleukin-15 Protein-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human IL-15 / Interleukin-15 Protein-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human IL-15 / Interleukin-15 Protein-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033630

      Synonyms:IL-15;Interleukin 15;IL15

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $178

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      Overview

      Synonyms IL-15;Interleukin 15;IL15
      Species Human
      Expression_host E.coli
      Sequence Asn49-Ser162
      Accession P40933
      Application Cell Culture
      Mol_Mass 12.5 kDa
      AP_Mol_Mass 12 kDa
      Bio_Activity Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 40-200pg/ml.

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.0.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Human Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature Human IL-15 shares 70% amino acid sequence identity with Mouse and Rat IL-15.

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      MSDS for ELISA ISO 9001

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