Synonyms	Inosine Triphosphate Pyrophosphatase;ITPase;Inosine Triphosphatase;Non-Canonical Purine NTP Pyrophosphatase;Non-Standard Purine NTP Pyrophosphatase;Nucleoside-Triphosphate Diphosphatase;Nucleoside-Triphosphate Pyrophosphatase;NTPase;Putative Oncogene Protein hlc14-06-p;ITPA;C20orf37
Species	Human
Expression_host	E.coli
Sequence	Ala2-Ala194
Accession	Q9BY32
Mol_Mass	22.5 kDa
AP_Mol_Mass	21 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 5% Trehalose, 300mM NaCl, 30% Glycerol, 0.05% Tween 80, pH8.0.
Reconstitution	Not Applicable

Background

Inosine Triphosphate Pyrophosphatase (ITPase) is a cytoplasmic enzyme that belongs to the HAM1 NTPase family. ITPase hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP) and deoxyinosine triphosphate (dITP) to the monophosphate nucleotide (IMP) and diphosphate. The ITPase enzyme acts as a homodimer and does not distinguish between the deoxy- and ribose forms. ITPase probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. Defects in ITPase is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.

Citations

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