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Recombinant Human KIM-1(C-6His)

Uniprot : F1CME6
  • Cat.No.:PKSH033813

  • Expression host: HEK293 Cells

To Purchase PKSH033813

Size:
  • 1mg
Price: $1180
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Description

Synonyms HAVCR1;HAVCR;HAVCR-1;KIM-1;KIM1;TIM;TIM-1;TIM1;TIMD-1;TIMD1;Hepatitis A virus cellular receptor 1
Species Human
Expression_host HEK293 Cells
Sequence Ser21-Gly290
Accession F1CME6
Mol_Mass 29.8 kDa
AP_Mol_Mass 80-120 kDa
Tag C-His

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin level Please contact us for more information.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μM filtered solution of PBS,pH7.4,5% Trehalose
Reconstitution Not Applicable

Background

Kidney injury molecule-1 (KIM-1) (also known as TIM-1 and HAVCR) is a type 1 transmembrane glycoprotein found on activated CD4+ T cells, especially Th2 cells, and dedifferentiated proximal tubule epithelial cells. In humans, KIM-1 levels are very low or undetectable in normal samples, but following drug toxicity or ischemic damage to the kidney, the 85 kD, mucin-rich extracellular region of this molecule is shed and detected at elevated levels in urine, serum, and plasma. Therefore, KIM-1 is a suitable renal biomarker capable of early detection and progressive monitoring of acute kidney injury beyond traditional injury markers such as serum creatinine (SCr) and blood urea nitrogen (BUN) which lack specificity and sensitivity. KIM-1 has also been implicated in the development of atopic airway disease (asthma) and Th2-biased autoimmune responses.

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