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Recombinant Human M-CSF/CSF1 Protein (Active)

Uniprot : NP_757349.1
  • Cat.No.:PKSH031969

  • Expression host: HEK293 Cells

To Purchase PKSH031969

  • 20µg
Price: $363


Synonyms Macrophage Colony-Stimulating Factor 1, CSF-1, M-CSF, MCSF, Lanimostim, CSF1, SCF-1
Species Human
Expression_host HEK293 Cells
Sequence Met 1-Asn190
Accession NP_757349.1
Application Cell Culture
Mol_Mass 18.4 kDa
Tag None
Bio_Activity Measured in a cell proliferation assay using M‑NFS‑60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 1. 6-6. 3 ng/mL.


Purity > 85 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from sterile PBS, pH 7.4. 5% Trehalose, 5% Mannitol, 0.01% Tween-80
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed
Reconstitution Please refer to the printed manual for detailed information.


Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M-CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.

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  • Q&A

y**aSubmitted [ Aug 04 2023 ]

Asked: Hi, in the reconstruction procedure in the printed manual instructed to prepare a stock solution of 0.25 mg/ml from 20 μg vial



adminSubmitted [ Aug 04 2023 ]



adminSubmitted [ Aug 04 2023 ]

Answered: It is recommended that sterile water (80ul) be added to the vial (20ug) to prepare a stock solution of 0.25mg/mL.

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