Synonyms	Endoplasmic Reticulum Mannosyl-Oligosaccharide 1;2-Alpha-Mannosidase;ER Alpha-1;2-Mannosidase;ER Mannosidase 1;ERMan1;Man9GlcNAc2-Specific-Processing Alpha-Mannosidase;Mannosidase Alpha Class 1B Member 1;MAN1B1
Species	Human
Expression_host	HEK293 Cells
Sequence	Asp106-Ala699
Accession	Q9UKM7
Mol_Mass	68.7 kDa
AP_Mol_Mass	58-80 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl,10mM reduced Glutathione,pH 8.0.
Reconstitution	Not Applicable

Background

Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.

Citations

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