Recombinant Human MAP4K5 / MEKKK5 Protein (His & GST tag)

    • Recombinant Human MAP4K5 / MEKKK5 Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
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    • Recombinant Human MAP4K5 / MEKKK5 Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human MAP4K5 / MEKKK5 Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030349

      Synonyms:GCKR;KHS;KHS1;MAPKKKK5

      Size:
      • 20µg
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms GCKR;KHS;KHS1;MAPKKKK5
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-Tyr 846
      Accession NP_006566.2
      Mol_Mass 123 kDa
      AP_Mol_Mass 116 kDa
      Tag N-His & GST

      Properties

      Purity > 82 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 0.5mM TCEP, pH 8.5
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Mitogen-activated protein kinase kinase kinase kinase 5, also known as Kinase homologous to SPS1/STE20, MAPK/ERK kinase kinase kinase 5, MEK kinase kinase 5 and MAP4K5, is a cytoplasm protein which belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE20 subfamily. MAP4K5 is ubiquitously expressed in all tissues examined, with high levels in the ovary, testis and prostate. It contains one CNH domain and one protein kinase domain. MAP4K5 is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. MAP4K5 has been shown to interact with CRKL and TRAF2. This kinase was shown to activate Jun kinase in mammalian cells. MAP4K5 is an early component of MAP kinase signal cascades. It may play a role in the response to environmental stress. MAP4K5 appears to act upstream of the JUN N-terminal pathway.

      SDS-PAGE

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      MSDS for ELISA

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