Synonyms	Sialic Acid Synthase;N-Acetylneuraminate Synthase;N-Acetylneuraminate-9-Phosphate Synthase;N-Acetylneuraminic Acid Phosphate Synthase;N-Acetylneuraminic Acid Synthase;NANS;SAS
Species	Human
Expression_host	E.coli
Sequence	Met 1-Ser359
Accession	AAH19315.1
Mol_Mass	42.4 kDa
AP_Mol_Mass	42 kDa
Tag	N-His
Bio_Activity	Not validated for activity

Properties

Purity	> 80 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 100mM NaCl, pH 8.0.
Reconstitution	Not Applicable

Background

Sialic Acid Synthase (NANS) is an enzyme that contains one AFP-like domain. NANS is ubiquitous and plays a role in the biosynthetic pathways of sialic acids. NANS produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). It also can use N-acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively.

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