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Recombinant Human OX40/TNFRSF4 Protein (mFc Tag)

  • Cat.No.:PKSH033789

  • Expression host: Human Cells

To Purchase PKSH033789

Size:
  • 10μg
  • 50μg
Price: $117
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Description

Synonyms Recombinant Human OX40/TNFRSF4 Protein (C-mFc)
Species Human
Expression_host Human Cells
Sequence Leu29-Ala216
Accession P43489
Mol_Mass 46.8 kDa
AP_Mol_Mass 65-80 kDa
Tag C-mFc

Properties

Purity > 95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg as determined by the LAL method.
Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

OX40, also termed CD134 andT NFRSF4, is a Tcellco-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells(APCs). TheT-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

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