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Recombinant Human PD-L2/CD273 Protein (His & Avi Tag)

Uniprot : Q9BQ51

Cat.No.:PKSH033795
Expression host: HEK293 Cells

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Description

Synonyms	Programmed Cell Death 1 Ligand 2;PD-1 Ligand 2;PD-L2;PDCD1 Ligand 2;Programmed Death Ligand 2;Butyrophilin B7-DC;B7-DC;CD273;PDCD1LG2;B7DC;CD273;PDCD1L2;PDL2
Species	Human
Expression_host	HEK293 Cells
Sequence	Leu20-Pro219
Accession	Q9BQ51
Mol_Mass	25.4 kDa
AP_Mol_Mass	38-60 kDa
Tag	C-His-Avi

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed man
Reconstitution	Please refer to the printed manual for detailed information.

Background

Programmed Cell Death 1 Ligand 2 (PDCD1LG2) is a member of the BTN/MOG family. PDCD1LG2 contains one Ig-like C2-type domain and one Ig-like V-type domain. PDCD1LG2 is highly expressed in the heart; placenta; pancreas; lung and liver; it is weakly expressed in the spleen; lymph nodes; and thymus. PDCD1LG2 is involved in the costimulatory signal; essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PDCD1LG2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

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