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Recombinant Human PDGFRa/CD140a Protein (His Tag)

Cat:PKSH033564
Manual MSDS

Price: $ 268

Price: $ 92

Size:
50μg 10μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: P16234
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Product Details
Synonyms CD140A;PDGFR-2;PDGFR2;RHEPDGFRA;Platelet-derived growth factor receptor alpha;PDGFR-alpha;Alpha platelet-derived growth factor receptor;CD140 antigen-like family member A;Platelet-derived growth factor alpha receptor;Platelet-derived growth factor receptor 2
Species Human
Expression Host HEK293 Cells
Sequence Gln24-Glu524
Accession P16234
Calculated Molecular Weight 57.0 kDa
Observed Molecular Weight 93 kDa
Tag C-His
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background Platelet-derived Growth Factor Receptor Alpha (PDGF Rα) is an enzyme that belongs to the class III subfamily of receptor tyrosine kinases.It is a type I transmembrane glycoprotein, and can form homo- or hetero-dimeric receptors when engaged by dimers of the PDGF family of growth factors, PDGF Rα is strongly expressed in oligodendrocyte, lung, skin and intestinal progenitor cells and induced by inflammation or growth in culture, but is lowly expressed in most mesenchymal cells. PDGF Rα autophosphorylates upon dimerization, activating signaling cascades in PI-3kinase Ras-MAP kinase, and PLC-γ pathways. PDGF Rα has infulence on local gradients of epithelially produced PDGF-AA or PDGF-CC during formation of the cranial ,cardiac neural crest and interstitial kidney mesenchyme.