Recombinant Human PFK2 / PFKFB3 Protein (His & GST tag)

    • Recombinant Human PFK2 / PFKFB3 Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    <
    >
    • Recombinant Human PFK2 / PFKFB3 Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience
    • Recombinant Human PFK2 / PFKFB3 Protein (His & GST tag)-Elabscience
    • Recombinant protein products for various applications-Elabscience

      Catalog number:PKSH030329

      Synonyms:IPFK2;PFK2

      Size:
      • 50µg
      Qty:
      - +
      Price: $486

      Lead Time: 7~10 daysWelcome to order from local distributors.

      Add to cart Compare Bulk request Manual

      Overview

      Synonyms IPFK2;PFK2
      Species Human
      Expression_host Baculovirus-Insect Cells
      Sequence Met 1-His 520
      Accession Q16875-1
      Mol_Mass 87.4 kDa
      AP_Mol_Mass 75 kDa
      Tag N-His & GST

      Properties

      Purity > 85 % as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per µg as determined by the LAL method.
      Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
      Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
      Formulation Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.0, 10% glycerol, 0.3mM DTT
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Fructose-2,6-biphosphatase 3, also known as 6-phosphofructo-2-kinase or PFK2 or PFKFB3, is a potent activator of phosphofructokinase, which is a rate-limiting enzyme of glycolysis. Highly phosphorylated PFKFB3 protein was found in human tumor cells, vascular endothelial cells, and smooth muscle cells. Fructose 2,6-bisphosphate (Fru-2,6-BP) is an allosteric activator of 6-phosphofructo-1-kinase (PFK-1), a rate-limiting enzyme and essential control point in glycolysis. The concentration of PFK2 depends on the activity of the bifunctional enzyme, 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase (PFK-2 / FBPase). PFK2 controls the glycolytic flux via the allosteric activator fructose 2,6-bisphosphate. Because of its proto-oncogenic character, the PFK-2/FBPase-2 of the PFKFB3 gene is assumed to play a critical role in tumorigenesis. The hypoxia-inducible form of 6-phosphofructo-2-kinase / fructose-2,6-bisphosphatase (PFKFB3) plays a crucial role in the progression of cancerous cells by enabling their glycolytic pathways even under severe hypoxic conditions.

      SDS-PAGE

      • Show all (0)
      • Reviews (0)
      • Q&A (0)
      ... Show All Show Less
      MSDS for ELISA

      Browsing History


        People Also Bought