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Recombinant Human POMGNT1 Protein (His Tag)

Uniprot : Q8WZA1
  • Cat.No.:PKSH032917

  • Expression host: HEK293 Cells

To Purchase PKSH032917

Size:
  • 10μg
  • 50μg
Price: $223
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Description

Synonyms Protein O-Linked-Mannose Beta-1;2-N-Acetylglucosaminyltransferase 1;POMGnT1;UDP-GlcNAc:Alpha-D-Mannoside Beta-1;2-N-Acetylglucosaminyltransferase I.2;POMGNT1;MGAT1.2
Species Human
Expression_host HEK293 Cells
Sequence Leu59-Thr660
Accession Q8WZA1
Mol_Mass 69.3 kDa
AP_Mol_Mass 74 kDa
Tag C-His

Properties

Purity > 90 % as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.
Reconstitution Not Applicable

Background

Protein O-Linked-Mannose β-1 2-N-Acetylglucosaminyltransferase 1 (POMGNT1) belongs to the Glycosyltransferase 13 family. Amino acid residues between 299-311 are important for both protein expression and enzymatic activity. The minimal catalytic domain is located between positions 299-651. It is suggested that the stem domain of the soluble form is unnecessary for activity, but that some amino acids play a crucial role in the membrane-bound form. Defects in POMGNT1 are the cause of muscular dystrophy-dystroglycanopathy congenital with brain and eye anomalies type A3 (MDDGA3).

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