Synonyms	Peptidyl-Prolyl Cis-Trans Isomerase H;PPIase H;Rotamase H;Small Nuclear Ribonucleoprotein Particle-Specific Cyclophilin H;CypH;U-snRNP-Associated Cyclophilin SnuCyp-20;USA-CYP;PPIH;CYP20;CYPH
Species	Human
Expression_host	E.coli
Sequence	Met 1-Met 177
Accession	O43447
Mol_Mass	21.4 kDa
AP_Mol_Mass	24 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of PBS, pH7.4.
Reconstitution	Not Applicable

Background

Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerization of Proline Imidic peptide bonds in oligopeptides. PPIH participates in pre-mRNA splicing. It is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. In addition, PPIH has PPIase activity and may play a role as a chaperone mediating the interactions between different proteins inside the spliceosome.

Citations

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