Synonyms	Lysosomal Pro-X Carboxypeptidase;Angiotensinase C;Lysosomal Carboxypeptidase C;Proline Carboxypeptidase;Prolylcarboxypeptidase;PRCP;PRCP;PCP
Species	Human
Expression_host	HEK293 Cells
Sequence	Leu22-His496
Accession	P42785
Mol_Mass	54.5 kDa
AP_Mol_Mass	60-90 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM NaAc-HAc, 150mM NaCl, 10% Glycerol, pH4.5.
Reconstitution	Not Applicable

Background

Lysosomal Pro-X Carboxypeptidase (PRCP) belongs to the peptidase S28 family. PRCP is detected in many tissues, with highest levels observed in placenta, lung, and liver. It is also present in the heart, brain, pancreas, and kidney. PRCP exists as a homodimer. PRCP cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. PRCP has been shown to be an activator of the cell matrix-associated prekallikrein.

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