Synonyms	Phosphoserine Phosphatase;PSP;PSPase;L-3-Phosphoserine Phosphatase;O-Phosphoserine Phosphohydrolase;PSPH
Species	Human
Expression_host	E.coli
Sequence	Met 1-Glu225
Accession	P78330
Mol_Mass	26.1 kDa
AP_Mol_Mass	25-30 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 4M Urea, 5mM EDTA, pH 8.0.
Reconstitution	Not Applicable

Background

Phosphoserine phosphatase (PSP) is an enzyme that belongs to the serB family. PSPH catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Deficiency of this protein is thought to be linked to Williams syndrome. A disorder that results in pre- and postnatal growth retardation; moderate psychomotor retardation and facial features suggestive of Williams syndrome.

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