Recombinant Human Renin Protein (His Tag)

    • Recombinant Human Renin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human Renin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human Renin Protein (C-His)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033540

      Synonyms:Renin; Angiotensinogenase; REN; Angiotensin-forming enzyme

      Size:
      • 10μg
      • 50μg
      Qty:
      - +
      Price: $111

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      Overview

      Synonyms Renin; Angiotensinogenase; REN; Angiotensin-forming enzyme
      Species Human
      Expression_host Human Cells
      Sequence Leu24-Arg406
      Accession P00797
      Mol_Mass 44 kDa
      AP_Mol_Mass 43-50 kDa
      Tag C-His

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Renin is a member of the aspartyl proteinase family produced largely in part by the juxtaglomerular cells in the kidney. Renin is produced as prorenin with 43 pro residues at the N-terminal of mature Renin. The inactive prorenin becomes activated proteolytically by trypsin, cathepsin B, or other proteinases. Renin also has a very high selectivity for substrates due to a long peptide recognition on either side of the peptide bond undergoing cleavage. An octapeptide substrate was the minimum length to be cleaved by Renin. Renin plays a crucial role in the regulation of blood pressure and salt balance through the cleavage of angiotensinogen,which is the only known physiological substrate of Renin. Renin releases the decapeptide angiotensin I, which in turn is further converted to vasoactive hormone angiotensin II by angiotensin converting enzyme (ACE).

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