Synonyms	Protein S100-A2;CAN19;Protein S-100L;S100 calcium-binding protein A2;S100A2;S100L
Species	Human
Expression_host	HEK293 Cells
Sequence	Met 2-Pro98
Accession	NP_005969.1
Mol_Mass	37.6 kDa
AP_Mol_Mass	40 kDa
Tag	N-hFc

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5 Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution	Please refer to the printed manual for detailed information.

Background

The calcium-binding Protein S100A2 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 family genes are located as a cluster on chromosome 1q21; and S100 proteins consisting of at least 20 members are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. S100A2 was first detected in lung and kidney; and is mainly expressed in a subset of tissues and cells such as breast epithelia and liver. The S100A2 protein is a homodimer that undergoes a conformational change upon binding of calcium; and the active form functions in regulating cell proliferation and differentiation; gene transcription; and p53-dependent growth arrest and apoptosis. Accordingly; this protein is regarded as a putative tumor suppressor; and thus chromosomal rearrangements and reduced expression of S100A2 gene have been implicated in certain carcinomas.

Citations

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