Synonyms	Sentrin-Specific Protease 8;Deneddylase-1;NEDD8-Specific Protease 1;Protease Cysteine 2;Sentrin/SUMO-Specific Protease SENP8;SENP8;DEN1;NEDP1;PRSC2
Species	Human
Expression_host	E.coli
Sequence	Met 1-Lys212
Accession	Q96LD8
Mol_Mass	26.2 kDa
AP_Mol_Mass	22 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Reconstitution	Not Applicable

Background

Sentrin-Specific Protease 8 (SENP8) mediates the reversible covalent modification of proteins by NEDD8. SENP8 catalyzes the full-length NEDD8 to generate its mature form and deconjugation of NEDD8 from targeted proteins such as CUL2 , CUL4A in vivo, or p53. but it does not show activity against ubiquitin or SUMO proteins.

Citations

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