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Recombinant Human SLAM Family Member 7/SLAMF7/CD319/CRACC (C-6His-Avi) Biotinylated

Cat:PKSH034057
Manual MSDS

Price: $ 924

Price: $ 342

Size:
100μg 20μg
Quantity:
  • Expression Host: HEK293 Cells
  • Accession: Q9NQ25
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Product Details
Synonyms SLAM Family Member 7;CD2 Subset 1;CD2-Like Receptor-Activating Cytotoxic Cells;CRACC;Membrane Protein FOAP-12;Novel Ly9;Protein 19A;CD319;SLAMF7;CS1
Species Human
Expression Host HEK293 Cells
Sequence Ser23-Met226
Accession Q9NQ25
Calculated Molecular Weight 25.2 kDa
Observed Molecular Weight 35-55 kDa
Tag C-His-Avi
Purity > 95 % as determined by reducing SDS-PAGE.
Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method.
Storage Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.
Reconstitution Please refer to the printed manual for detailed information.
Background SLAMF7 is a single-pass type I membrane protein and contains 1 Ig-like C2-type (immunoglobulin-like) domain. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. SLAMF7 positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, SLAMF7 can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
Modification Biotinylated