Synonyms	Beta-Galactoside Alpha-2;6-Sialyltransferase 1;Alpha 2;6-ST 1;B-Cell Antigen CD75;CMP-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2;6-Sialyltransferase 1;ST6Gal I;ST6GalI;Sialyltransferase 1;ST6GAL1;SIAT1
Species	Human
Expression_host	HEK293 Cells
Sequence	Lys27-Cys406
Accession	P15907
Mol_Mass	44.6 kDa
AP_Mol_Mass	41-60 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution	Not Applicable

Background

The ST6GAL1 gene encodes β-Galactosamide α-2;6-Sialyltransferase 1. It is a type II membrane protein and is localized to the trans-Golgi network. It catalyzes 2;6-sialylation of Galβ1;4-GlcNAc structures on N-glycans. ST6GAL1 is highly expressed in the liver and other tissues. ST6GAL1 deficiency causes abnormalities in B-cell immunoreactivity. The expression and activity of ST6GAL1 are associated with tumor metastasis in breast and colon cancers. The majority of ST6GAL1 in the liver is cleaved and secreted into the serum and may be used as a biomarker for hepatitis diseases.

Citations

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