Synonyms	Sulfotransferase 1A1;ST1A1;Aryl sulfotransferase 1;HAST1/HAST2;Phenol Sulfotransferase 1;Phenol-Sulfating Phenol Sulfotransferase 1;P-PST 1;ST1A3;Thermostable Phenol Sulfotransferase;Ts-PST;SULT1A1;STP;STP1;OK/SW-cl.88
Species	Human
Expression_host	E.coli
Sequence	Met 1-Leu295
Accession	AAH00923.1
Mol_Mass	35.6 kDa
AP_Mol_Mass	32 kDa
Tag	N-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM PB, 10% Trehalose, 50mM Nacl, 0.05% Tween 80, pH7.8.
Reconstitution	Not Applicable

Background

Sulfotransferase 1A1 (SULT1A1) is a cytosolic sulfotransferases that is expressed in the liver; lung; adrenal; brain; platelets; and skin. SULT1A1 is a phenol sulfotransferases with thermostable enzyme activity. SULT1A1 utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines; phenolic drugs and neurotransmitters. It is responsible for the sulfonation and activation of minoxidil. SULT1A1 mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk.

Citations

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