Recombinant Human TIM-3/HAVCR2 Protein (mFc Tag)

    • Recombinant Human TIM-3 / HAVCR2 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human TIM-3 / HAVCR2 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human TIM-3 / HAVCR2 Protein (C-mFc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033790

      Synonyms:Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3; HAVCR2; TIM3; TIMD3

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      • 10μg
      • 50μg
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      Price: $129

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      Overview

      Synonyms Hepatitis A virus cellular receptor 2; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; TIMD-3; T-cell immunoglobulin mucin receptor 3; TIM-3; T-cell membrane protein 3; HAVCR2; TIM3; TIMD3
      Species Human
      Expression_host Human Cells
      Sequence Ser22-Arg200(Arg140Leu)
      Accession Q8TDQ0
      Mol_Mass 46.4 kDa
      AP_Mol_Mass 55 kDa
      Tag C-mFc

      Properties

      Purity > 80% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Hepatitis A virus cellular receptor 2 (HAVCR2) is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

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      MSDS for ELISA ISO 9001

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