Recombinant Human TNFSF14/LIGHT Protein (mFc Tag)

    • Recombinant Human LIGHT / TNFSF14 / CD258 Protein (N-mFc)-Elabscience
    • Recombinant Protein-Elabscience
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    • Recombinant Human LIGHT / TNFSF14 / CD258 Protein (N-mFc)-Elabscience
    • Recombinant Protein-Elabscience
    • Recombinant Human LIGHT / TNFSF14 / CD258 Protein (N-mFc)-Elabscience
    • Recombinant Protein-Elabscience

      Catalog number:PKSH033497

      Synonyms:CD258;HVEML;LIGHT;LTg;TR2;Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; TNFSF14; HVEM-L; LIGHT

      Size:
      • 10μg
      • 50μg
      Qty:
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      Price: $92

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      Overview

      Synonyms CD258;HVEML;LIGHT;LTg;TR2;Tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; TNFSF14; HVEM-L; LIGHT
      Species Human
      Expression_host Human Cells
      Sequence Ile84-Val240(Lys214Glu)
      Accession O43557
      Mol_Mass 43.3 kDa
      AP_Mol_Mass 45-60 kDa
      Tag N-mFc

      Properties

      Purity > 95% as determined by reducing SDS-PAGE.
      Endotoxin < 1.0 EU per μg as determined by the LAL method.
      Storage Lyophilized protein should be stored at < -20℃, though stable at room temperature for 3 weeks.Reconstituted protein solution can be stored at 4-7℃ for 2-7 days.Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
      Shipping This product is provided as lyophilized powder which is shipped with ice packs.
      Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
      Reconstitution Please refer to the printed manual for detailed information.

      Background

      Human TNFSF14 Protein, also known as LIGHT, belongs to a member of the tumor necrosis factor (TNF) ligand family. It can bind to NFRSF3/LTBR. It is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and it is also known as a herpesvirus entry mediator ligand (HVEML). TNFSF14 encodes a protein with a 37 aa cytoplasmic domain, 21aa transmembrane domain and 182 aa extracellular region. The gene is predominantly expressed in the spleen and also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines. TNFSF14 protein was found to probably function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. Studies have shown that this protein can prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.

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      MSDS for ELISA ISO 9001

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