Synonyms	Tripeptidyl-Peptidase 1;TPP-1;Cell Growth-Inhibiting Gene 1 Protein;Lysosomal Pepstatin-Insensitive Protease;LPIC;Tripeptidyl Aminopeptidase;TPP1;CLN2;GIG1;LPIC;SCAR7;TPP-1
Species	Human
Expression_host	HEK293 Cells
Sequence	Ser20-Pro563
Accession	AAH14863.1
Mol_Mass	60.4 kDa
AP_Mol_Mass	74 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 1mM CaCl₂, 10% Glycerol, pH 7.5.
Reconstitution	Not Applicable

Background

Tripeptidyl-Peptidase 1 (TPP1) belongs to the peptidase S53 family. TPP1 is detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. TPP1 is lysosomal serine protease with tripeptidyl-peptidase I activity. TPP1 may act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. TPP1 requires substrates with an unsubstituted N-terminus. TPP1 mutations have also been shown to cause neuronal ceroid lipofuscinosis type 2 (CLN2).

Citations

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