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Recombinant Human Transforming Growth Factor Beta-1/TGFB1 Biotinylated

Uniprot : P01137

Cat.No.:PKSH034059
Expression host: HEK293 Cells

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Description

Synonyms	Transforming Growth Factor Beta-1;TGF-Beta-1;Latency-Associated Peptide;LAP;TGFB1;TGFB
Species	Human
Expression_host	HEK293 Cells
Sequence	Ala279-Ser390
Accession	P01137
Mol_Mass	14.6 kDa
AP_Mol_Mass	12-18 kDa
Tag	N-Avi
Bio_Activity	Measured by its ability to inhibit TGF-beta 1 activity on TF‑1 human erythroleukemic cells.The ED₅₀ for this effect is 137.37pg/ml.

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 0.01 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 50mM Glycine-HCl, 150mM NaCl, pH2.5. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the pri
Reconstitution	Please refer to the printed manual for detailed information.

Background

Transforming Growth Factor β-1 (TGFβ-1) is a secreted protein which belongs to the TGF-β family. TGFβ-1 is abundantly expressed in bone, articular cartilage and chondrocytes and is increased in osteoarthritis (OA). TGFβ-1 performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The precursor is cleaved into a latency-associated peptide (LAP) and a mature TGFβ-1 peptide. TGFβ-1 may also form heterodimers with other TGFβ family members. It has been found that TGFβ-1 is frequently upregulated in tumor cells. Mutations in this gene results in Camurati-Engelmann disease.

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