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Recombinant Human Tropomyosin α-3 Chain/TPM3 Protein

Uniprot : P06753

Cat.No.:PKSH033151
Expression host: E.coli

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Description

Synonyms	Tropomyosin Alpha-3 Chain;Gamma-Tropomyosin;Tropomyosin-3;Tropomyosin-5;hTM5;TPM3
Species	Human
Expression_host	E.coli
Sequence	Met 1-Met248
Accession	P06753-2
Mol_Mass	29.0 kDa
AP_Mol_Mass	32 kDa
Tag	None

Properties

Purity	> 90 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual
Reconstitution	Please refer to the printed manual for detailed information.

Background

Tropomyosin Alpha-3 Chain (TPM3) is a member of the Tropomyosin family. TPM3 exists as a heterodimer consisting of an alpha and a beta chain. TPM3 plays a central role in association with the Troponin complex and in the calcium dependent regulation of vertebrate striated muscle contraction. Defects in TPM3 are the cause of thyroid papillary carcinoma. Mutations in the TPM3 gene cause autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are linked with cancer.

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