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Recombinant Human TSLP R/CRLF2 (C-Fc)

Uniprot : Q9HC73
  • Cat.No.:PKSH033923

  • Expression host: Human Cells

To Purchase PKSH033923

Size:
  • 10µg
  • 50µg
Price: $132
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Description

Synonyms CRL2; CRL2cytokine receptor CRL2 precusor; CRLF2; CRLF2Y; CRLM-2; Cytokine receptor-like 2;cytokine receptor-like factor 2; ILXR; IL-XR; P2RY8/CRLF2 fusion; PCOR1; TSLP R; TSLP receptor;TSLPR
Species Human
Expression_host Human Cells
Sequence Gly25-Lys231
Accession Q9HC73
Mol_Mass 50.9 kDa
AP_Mol_Mass 60-80 kDa
Tag C-Fc
Bio_Activity Loaded Human TSLP-His(Cat#PKSH033888) on HIS1K Biosensor, can bind Human TSLP R-Fc(Cat#PKSH033923) with an affinity constant of 37.97nM as determined in BLI assay.

Properties

Purity >95% as determined by reducing SDS-PAGE.
Endotoxin level < 1.0 EU per µg as determined by the LAL method.
Storage Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Shipping This product is provided as lyophilized powder which is shipped with ice packs.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Please refer to the printed manual for detailed information.

Background

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. TSLP R expression is ubiquitous in the immune and hematopoietic cells, but is up-regulated in Th2-skewed cells. Cells expressing TSLP R alone bind TSLP with low affinity. Co-expression of TSLP R and IL-7 R alpha is required for high-affinity TSLP binding and signal transduction . The TSLP R and IL-7 R alpha are coexpressed primarily on monocytes and dendritic cells and at lower levels in lymphoid cells. TSLP has been shown to induce the release of T cell-attracting chemokines from monocytes and enhance the maturation of CD11c+ dendritic cells.

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