Synonyms	GDP-L-Fucose Synthase;GDP-4-Keto-6-Deoxy-D-Mannose-3;5-Epimerase-4-Reductase;Protein FX;Red Cell NADP(H)-Binding Protein;Short-Chain Dehydrogenase/Reductase Family 4E Member 1;TSTA3;SDR4E1
Species	Human
Expression_host	E.coli
Sequence	Met 1-Lys321
Accession	Q13630
Mol_Mass	37.0 kDa
AP_Mol_Mass	40 kDa
Tag	C-His

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, pH 8.0.
Reconstitution	Not Applicable

Background

GDP-L-Fucose Synthase is a NADP(H)-binding protein. It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-dexoymannose to GDP-L-fucose. GDP-L-Fucose is the substrate of several fucosyltransferase, involving the expression of mamy glycoconjugates, including blood group ABH antigens and development adhesion antigens. Mutations in the TSTA3 gene may cause leukocyte adhesion deficiency type II.

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