Recombinant Human UBE2A Protein (His Tag) (PKSH030787)
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For research use only.
| Synonyms | hHR6A, HR6A, RAD6 Homolog A, RAD6A, UBE2A, Ubiquitin Carrier Protein A, Ubiquitin-Conjugating Enzyme E2 A, Ubiquitin-Protein Ligase A |
| Species | Human |
| Expression Host | E.coli |
| Sequence | Met 1-Cys 152 |
| Accession | P49459 |
| Calculated Molecular Weight | 19.2 kDa |
| Observed Molecular Weight | 18.5 kDa |
| Tag | N-His |
| Bio-activity | Not validated for activity |
| Form | Liquid |
| Purity | > 80 % as determined by reducing SDS-PAGE. |
| Endotoxin | Please contact us for more information. |
| Storage | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
| Shipping | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C. |
| Formulation | Supplied as sterile PBS, 20% glycerol, pH 7.5 |
| Background | Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A); encoded by human DNA repair genes HHR6A; belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be involved in postreplication repair and induced mutagenesis. UBE2A is described as a CDK2 substrate. It is the human homologue of the product of the Saccharomyces cerevisiae RAD6 / UBC2 gene; a member of the family of ubiquitin-conjugating enzymes. In vivo; HHR6A phosphorylation peaks during the G2/M phase of cell cycle transition; with a concomitant increase in histone H2B ubiquitylation. Mutation of Ser120 to threonine or alanine abolished UBE2A activity; while mutation to aspartate to mimic phosphorylated serine increased UBE2A activity 3-fold. A mutation of UBE2A is consisdered as the cause of a novel X-linked mental retardation (XLMR) syndrome that affects three males in a two-generation family. |
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