Synonyms	Ubiquitin-Conjugating Enzyme E2 B;RAD6 Homolog B;HR6B;hHR6B;Ubiquitin Carrier Protein B;Ubiquitin-Conjugating Enzyme E2-17 kDa;Ubiquitin-Protein Ligase B;UBE2B;RAD6B
Species	Human
Expression_host	E.coli
Sequence	Met 1-Ser152
Accession	P63146
Mol_Mass	17.5 kDa
AP_Mol_Mass	18 kDa
Tag	None

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 10mM HEPES, pH 7.5.
Reconstitution	Not Applicable

Background

Ubiquitin-Conjugating Enzyme E2 B (UBE2B) belongs to the ubiquitin-conjugating enzyme family. UBE2B can catalyze the covalent attachment of ubiquitin to other proteins; and is essential for the multi-ubiquitination and degradation of N-end rule substrates. UBE2B is indispensability for postreplication repair of UV-damaged DNA and may be involved in neurite outgrowth.Additionally; UBE2B may have a role in sepsis-induced muscle protein proteolysis and cancer-induced cachexia.

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