Synonyms	SUMO-Conjugating Enzyme UBC9;SUMO-Protein Ligase;Ubiquitin Carrier Protein 9;Ubiquitin Carrier Protein I;Ubiquitin-Conjugating Enzyme E2 I;Ubiquitin-Protein Ligase I;p18;UBE2I;UBC9;UBCE9
Species	Human
Expression_host	E.coli
Sequence	Met 1-Ser158
Accession	P63279
Mol_Mass	44.4 kDa
AP_Mol_Mass	40 kDa
Tag	N-GST

Properties

Purity	> 95 % as determined by reducing SDS-PAGE.
Endotoxin level	< 1.0 EU per μg of the protein as determined by the LAL method.
Storage	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Shipping	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Formulation	Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, pH 7.5.
Reconstitution	Not Applicable

Background

SUMO-Conjugating Enzyme UBC9 (UBC9) belongs to the ubiquitin-conjugating enzyme family. UBC9 is homologous to ubiquitin-conjugating enzymes (E2s). However; instead of conjugating ubiquitin; UBC9 conjugates a ubiquitin homologue; Small Ubiquitin-Like Modifier 1 (SUMO-1). The conjugation of ubiquitin requires the activities of ubiquitin-activating (E1) and conjugating (E2) enzymes. It is suggested that UBC9 might play a role in DNA repair and perhaps even in aging.

Citations

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